Difference between revisions of "Computational Medicine"

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(Created page with "There is no consistent definition of //computational medicine// yet. So I will come up with my own general definition for now: Computational medicine is the application of com...")
 
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[http://www.computational.ch/research/default.html Zürich Computational Medicine Research Group ]
 
[http://www.computational.ch/research/default.html Zürich Computational Medicine Research Group ]
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[https://tu-dresden.de/med/mf/imb/forschung/arbeitsgruppen-am-imb/ag-roeder-medizinische-systembiologie-und-biometrie TU Dresden - Medical Systems Biology]
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[https://www.dkfz.de/en/medphys/computational-patient-models/mainpage.html DZKF - Computational Patient Models]
  
 
[http://www.zib.de/numeric/computational-medicine Zuse Institute Berlin ]
 
[http://www.zib.de/numeric/computational-medicine Zuse Institute Berlin ]
  
 
[https://med.nyu.edu/institute-computational-medicine/ NYU Institute for Computational Medicine ]
 
[https://med.nyu.edu/institute-computational-medicine/ NYU Institute for Computational Medicine ]
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[https://www.wias-berlin.de/research/mfs/biomed/index.jsp?lang=0 Weierstrass Institut Berlin - Quantitative Biomedicine]
  
  
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=== Relevant Groups, Projects and Methods ===
 
=== Relevant Groups, Projects and Methods ===
[http://www.scs.illinois.edu/schulten/lm/ Lattice Microbes ]
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[http://www.scs.illinois.edu/schulten/lm/ Lattice Microbes]
  
 
[http://vcell.org/ Virtual Cell]
 
[http://vcell.org/ Virtual Cell]
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[http://www.compucell3d.org/ CompuCell3D - Virtual Tissue in-silico simulation]
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[morpheus.gitlab.io Morpheus - A modeling and simulation environment for the study of multi-scale and multicellular systems]
  
 
[https://sites.google.com/site/premertoolbox/ Parallel Reverse Engineering with Mutual information & Entropy Reduction]
 
[https://sites.google.com/site/premertoolbox/ Parallel Reverse Engineering with Mutual information & Entropy Reduction]
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[http://www.sciencedirect.com/science/book/9780124059269  Computational Systems Biology - From Molecular Mechanisms to Disease]
 
[http://www.sciencedirect.com/science/book/9780124059269  Computational Systems Biology - From Molecular Mechanisms to Disease]
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[https://www.ncbi.nlm.nih.gov/pubmed/21483730 A computational systems biology software platform for multiscale modeling and simulation integrating whole-body physiology, disease biology, and molecular reaction networks]
 
[https://www.ncbi.nlm.nih.gov/pubmed/21483730 A computational systems biology software platform for multiscale modeling and simulation integrating whole-body physiology, disease biology, and molecular reaction networks]
[http://www.openworm.org/ | OpenWorm ]]
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[http://www.openworm.org/ OpenWorm ]
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[https://physionet.org/ PhysioNet - Resource for physiological signals]
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[https://tu-dresden.de/zih/forschung/projekte/space_sys SpaceSys - Spatio-Temporal Dynamics in Systems Biology]
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[https://cfaed.tu-dresden.de/biological-systems
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Center for Advancing Electronics Dresden - Biological Systems]

Revision as of 01:12, 15 December 2018

There is no consistent definition of //computational medicine// yet. So I will come up with my own general definition for now: Computational medicine is the application of computing methods to model, simulate and visualize medical processes in a virtual environment.

//Computational Medicine// is commonly divided into four areas. For now I take the definition by JHU to clarify what Computational Medicine covers.

  • Computational Molecular Medicine (pharmacogenomics, metagenomics, ...)
  • Computational Physiology (disease process models, pharmacokinectic/pharmatcodynamic models, ...)
  • Computational Anatomy (imaging, implantable devices, ...)
  • Computational Healthcare (epidemiology, medical apps, ... )

For details look into the following paper: Computational Medicine - Translating Models to Clinical Care

Propsed Focus

  • Dynamics of affective disorders (cellular, tissue, organ, psychical, social)
  • Tissue healing processes after severve trauma (cellular, tissue, organ, organ system)
  • Multi-scale tumor dynamics (molecular, cellular, tissue, organ)
  • Computational surgery with focus on neuro and trauma surgery (tissue, organ, organ system, organism)
  • Modeling techniques for physiological pathophysiological processes
  • Foundational algorithms of tissue formation

Journals

https://www.hindawi.com/journals/cmmm/contents/

http://journal.frontiersin.org/journal/all/section/computational-physiology-and-medicine

Research Groups and Projects

JHU Institute for Computational Medicine

Physiome Project

MOSAIC MPI-CBG Dresden

Mathcancer / Macklin Lab, Indiana University

IT'IS Foundation

CSElab Zürich

Zürich Computational Medicine Research Group

TU Dresden - Medical Systems Biology

DZKF - Computational Patient Models

Zuse Institute Berlin

NYU Institute for Computational Medicine

Weierstrass Institut Berlin - Quantitative Biomedicine


Some interesting papers

Grand Challanges in Computational Physiology and Medicine

Simulation and Optimization of Fracture Healing

Modeling the Dynamics of Disease States in Depression

Modeling Tumor Vasculature : Molecular, Cellular, and Tissue Level Aspects and Implications

Cardiac electromechanical models: from cell to organ

Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

Modeling and Simulation of the Immune System as a Self-Regulating Network



Relevant Groups, Projects and Methods

Lattice Microbes

Virtual Cell

CompuCell3D - Virtual Tissue in-silico simulation

[morpheus.gitlab.io Morpheus - A modeling and simulation environment for the study of multi-scale and multicellular systems]

Parallel Reverse Engineering with Mutual information & Entropy Reduction

OpenDreamkit

Predictive Cancer Pathway Modelling

Tusscher Group, Unviersity of Utrecht

Hermsen Group, University of Utrecht

HHU, AG Computational Cell Biology

BioCAE: A New Strategy of Complex Biological Systems for Biofabrication of Tissues and Organs

Computational Systems Biology - From Molecular Mechanisms to Disease

A computational systems biology software platform for multiscale modeling and simulation integrating whole-body physiology, disease biology, and molecular reaction networks

OpenWorm

PhysioNet - Resource for physiological signals

SpaceSys - Spatio-Temporal Dynamics in Systems Biology

[https://cfaed.tu-dresden.de/biological-systems Center for Advancing Electronics Dresden - Biological Systems]