Computational Medicine
There is no consistent definition of //computational medicine// yet. So I will come up with my own general definition for now: Computational medicine is the application of computing methods to model, simulate and visualize medical processes in a virtual environment.
//Computational Medicine// is commonly divided into four areas. For now I take the definition by JHU to clarify what Computational Medicine covers.
- Computational Molecular Medicine (pharmacogenomics, metagenomics, ...)
- Computational Physiology (disease process models, pharmacokinectic/pharmatcodynamic models, ...)
- Computational Anatomy (imaging, implantable devices, ...)
- Computational Healthcare (epidemiology, medical apps, ... )
For details look into the following paper: Computational Medicine - Translating Models to Clinical Care
Contents
Propsed Focus
- Dynamics of affective disorders (cellular, tissue, organ, psychical, social)
- Tissue healing processes after severve trauma (cellular, tissue, organ, organ system)
- Multi-scale tumor dynamics (molecular, cellular, tissue, organ)
- Computational surgery with focus on neuro and trauma surgery (tissue, organ, organ system, organism)
- Modeling techniques for physiological pathophysiological processes
- Foundational algorithms of tissue formation
Journals
https://www.hindawi.com/journals/cmmm/contents/
http://journal.frontiersin.org/journal/all/section/computational-physiology-and-medicine
Research Groups and Projects
JHU Institute for Computational Medicine
Mathcancer / Macklin Lab, Indiana University
Zürich Computational Medicine Research Group
NYU Institute for Computational Medicine
Some interesting papers
Grand Challanges in Computational Physiology and Medicine
Simulation and Optimization of Fracture Healing
Modeling the Dynamics of Disease States in Depression
Modeling Tumor Vasculature : Molecular, Cellular, and Tissue Level Aspects and Implications
Cardiac electromechanical models: from cell to organ
Modeling and Simulation of the Immune System as a Self-Regulating Network
Relevant Groups, Projects and Methods
Parallel Reverse Engineering with Mutual information & Entropy Reduction
Predictive Cancer Pathway Modelling
Tusscher Group, Unviersity of Utrecht
Hermsen Group, University of Utrecht
HHU, AG Computational Cell Biology
BioCAE: A New Strategy of Complex Biological Systems for Biofabrication of Tissues and Organs
Computational Systems Biology - From Molecular Mechanisms to Disease A computational systems biology software platform for multiscale modeling and simulation integrating whole-body physiology, disease biology, and molecular reaction networks | OpenWorm ]