Computational Medicine

There is no consistent definition of //computational medicine// yet. So I will come up with my own general definition for now: Computational medicine is the application of computing methods to model, simulate and visualize medical processes in a virtual environment.

//Computational Medicine// is commonly divided into four areas. For now I take the definition by JHU to clarify what Computational Medicine covers.

• Computational Molecular Medicine (pharmacogenomics, metagenomics, ...)
• Computational Physiology (disease process models, pharmacokinectic/pharmatcodynamic models, ...)
• Computational Anatomy (imaging, implantable devices, ...)
• Computational Healthcare (epidemiology, medical apps, ... )

For details look into the following paper: Computational Medicine - Translating Models to Clinical Care

Propsed Focus

• Dynamics of affective disorders (cellular, tissue, organ, psychical, social)
• Tissue healing processes after severve trauma (cellular, tissue, organ, organ system)
• Multi-scale tumor dynamics (molecular, cellular, tissue, organ)
• Computational surgery with focus on neuro and trauma surgery (tissue, organ, organ system, organism)
• Modeling techniques for physiological pathophysiological processes
• Foundational algorithms of tissue formation

Journals

https://www.hindawi.com/journals/cmmm/contents/

http://journal.frontiersin.org/journal/all/section/computational-physiology-and-medicine

Research Groups and Projects

JHU Institute for Computational Medicine

Physiome Project

MOSAIC MPI-CBG Dresden

Mathcancer / Macklin Lab, Indiana University

IT'IS Foundation

CSElab Zürich

Zürich Computational Medicine Research Group

TU Dresden - Medical Systems Biology

DZKF - Computational Patient Models

Zuse Institute Berlin

NYU Institute for Computational Medicine

Weierstrass Institut Berlin - Quantitative Biomedicine

Some interesting papers

Grand Challanges in Computational Physiology and Medicine

Simulation and Optimization of Fracture Healing

Modeling the Dynamics of Disease States in Depression

Modeling Tumor Vasculature : Molecular, Cellular, and Tissue Level Aspects and Implications

Cardiac electromechanical models: from cell to organ

Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

Modeling and Simulation of the Immune System as a Self-Regulating Network

Relevant Groups, Projects and Methods

Lattice Microbes

Virtual Cell

CompuCell3D - Virtual Tissue in-silico simulation

[morpheus.gitlab.io Morpheus - A modeling and simulation environment for the study of multi-scale and multicellular systems]

Parallel Reverse Engineering with Mutual information & Entropy Reduction

OpenDreamkit

Predictive Cancer Pathway Modelling

Tusscher Group, Unviersity of Utrecht

Hermsen Group, University of Utrecht

HHU, AG Computational Cell Biology

BioCAE: A New Strategy of Complex Biological Systems for Biofabrication of Tissues and Organs

Computational Systems Biology - From Molecular Mechanisms to Disease

A computational systems biology software platform for multiscale modeling and simulation integrating whole-body physiology, disease biology, and molecular reaction networks

OpenWorm

PhysioNet - Resource for physiological signals

SpaceSys - Spatio-Temporal Dynamics in Systems Biology

[https://cfaed.tu-dresden.de/biological-systems Center for Advancing Electronics Dresden - Biological Systems]